Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.contributor.advisor | Siu, Parco (HTI) | - |
| dc.creator | Yu, Sau Shun | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/8432 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | To investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly | en_US |
| dcterms.abstract | Metabolic syndrome (MetS) is a worldwide health problem, especially in elderly. In fact, MetS is closely related to cardiovascular diseases (CVDs) and diabetes (Newby, 2005). Matrix metalloproteinase-9 (MMP-9) is associated with CVDs, it is because abnormal level of MMP-9 would remodel the endothelial basal membrane, that promote erosion and thrombosis (Raffetto, et al., 2008). The extracellular matrix proteins, mainly the type IV collagen would be degraded by the MMP-9 (Balkau, et al., 2007). For this reason, the objective of this project is to investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly (aged over 60 years). In this study, serum MMP-9 levels were significantly different between subjects in MetS compared with the subjects in non-MetS group (P<0.05). All 5 MetS components including blood pressure, waist circumference, triglycerides, HDL-cholesterol and fasting blood glucose showed significant association with serum MMP-9 levels (P-<0.05). Systolic Blood Pressure (SBP) had the highest correlation coefficient (r=0.669) among other components. The effect of MMP-9 concentration showed significant difference with the number of MetS components (P<0.05). To conclude, the increasing of MMP-9 levels was mainly associated with high blood pressure in the elderly with MetS. Clinically, it was important to study the implications of MMP-9 in cardiovascular risk of MetS subjects. More studies should be carried on the prevention and management of MetS, especially in elderly. | en_US |
| dcterms.extent | x, 67 pages : illustrations | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2016 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Metabolic syndrome. | en_US |
| dcterms.LCSH | Metalloproteinases | en_US |
| dcterms.LCSH | Older people. | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b28641401.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.9 MB | Adobe PDF | View/Open |
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