Author: Po, Kai Ting
Title: The aversive effects of cough suppressants on neurogenesis and emotional behaviour : chronic exposure to a common active ingredient in cough suppressants causes emotional disturbances through the suppression of adult neurogenesis, and their prevention by wolfberry polysaccharide in rats
Advisors: Lau, Benson (RS)
Degree: M.Phil.
Year: 2017
Subject: Hong Kong Polytechnic University -- Dissertations
Medication abuse
Drug addiction
Drug addiction -- Treatment
Lycium chinense -- Therapeutic use
Department: Department of Rehabilitation Sciences
Pages: 126 pages : color illustrations
Language: English
Abstract: Cough syrup abuse is a worldwide problem with increasing prevalence, causing chronic disability to abusers. Clinical studies have revealed that abusive consumption of the cough medicine can lead to various psychiatric signs and symptoms including delusion, hallucination, anxiety and depression. These persistent psychiatric symptoms not only disturb the abusers, but are also heavy burdens to the healthcare system. However, the underlying mechanisms of these adverse effects remain elusive. In order to investigate the mechanisms as well as the possible adjunctive treatments, the objectives of the present study are: 1. To explore the effect of repeated, high-dose dextromethorphan (DXM, a common antitussive component in cough syrup) treatment on adult hippocampal neurogenesis; 2. to study the dose-response effect of DXM on neurogenesis, and 3. to investigate the potential effect of wolfberry (a traditional Chinese herb) polysaccharide on reducing emotional distress caused by repeated treatment of DXM. The results revealed that high-dose DXM treatment induced mood disturbances and suppressed neurogenesis, while wolfberry polysaccharide could reverse the undesirable effects. These findings suggest that neurogenesis may be an underlying mechanisms of emotional symptoms induced by DXM, and the result also provided insights for using wolfberry polysaccharide, an herbal component, as a possible adjunctive treatment for the rehabilitation of cough syrup abusers suffering from emotional signs and symptoms.
Rights: All rights reserved
Access: open access

Files in This Item:
File Description SizeFormat 
991021952840903411.pdfFor All Users2.41 MBAdobe PDFView/Open

Copyright Undertaking

As a bona fide Library user, I declare that:

  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.

By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

Show full item record

Please use this identifier to cite or link to this item: