| Author: | Lai, Lap Kwong Bert |
| Title: | An investigation of inter-relationships between vitamin D status, oxidative stress and glycemic control in patients with metabolic syndrome in Hong Kong |
| Advisors: | Benzie, Iris (HTI) Siu, Gilman (HTI) |
| Degree: | M.Sc. |
| Year: | 2017 |
| Subject: | Hong Kong Polytechnic University -- Dissertations Vitamin D -- Health aspects Vitamin D in human nutrition Oxidative stress Metabolic syndrome Diabetes |
| Department: | Department of Health Technology and Informatics |
| Pages: | xiv, 112 pages : illustrations |
| Language: | English |
| Abstract: | Introduction: Vitamin D has long been considered as an essential nutrient for bone health. Recently, the health effects other than musculoskeletal effects of vitamin D is also attracting much attention. Vitamin D had been shown inversely associated with incidence of cardiovascular diseases and other non-communicable diseases (NCDs) such as high blood pressure and diabetes mellitus. Vitamin D is also reported to be inversely associated with oxidative stress, a condition that is commonly related to dyslipidaemia and impaired glycaemic tolerance. These are key elements of the metabolic syndrome (MetSyn), a common condition that may advance to type 2 diabetes within a short period. Aim: This study aims to investigate the inter-relationship between vitamin D sufficiency and oxidative stress level, and explore if hypovitaminosis D is a modifiable risk factor for MetSyn. Method: Liquid chromatography with tandem mass spectrometry were used to evaluate vitamin D status (measuring 25-hydroxyvitamin D), oxidative stress (measuring urine 8-oxodG and plasma allantoin) and glycaemic status (measured by fasting plasma glucose, high density lipoprotein cholesterol and triglyceride) in MetSyn patient and control subjects. Correlational analyses were performed to investigate associations between biomarkers. Result: Plasma allantoin is significantly higher in MetSyn patients compared with control subjects. Significant differences for 25(OH)D and urine 8-oxodG could not be seen between MetSyn patients and control. The tested biomarkers showed no significant difference across vitamin D categories. Correlational analyses showed direct association between allantoin and FPG, and inverse association between allantoin and HDL-c, when all subjects were analyzed together. No other significant associations were identified in this study. Conclusion: The results provided extra evidence of the association between oxidative stress markers and the occurrence of MetSyn. Future researches with a bigger sample size is needed. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 991021962223403411.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.34 MB | Adobe PDF | View/Open |
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