Author: Lo, Ming Yuen Kevin
Title: A retrospective analysis of the association of target motion with target size, location and child-pugh score in stereotactic body radiation therapy of liver cancer
Advisors: Wu, Vincent (HTI)
Degree: DHSc
Year: 2018
Subject: Hong Kong Polytechnic University -- Dissertations
Liver -- Cancer -- Radiotherapy
Department: Faculty of Health and Social Sciences
Pages: vii, 70 pages : color illustrations
Language: English
Abstract: Purpose / Objective: To evaluate the association of target motion with target size (Gross tumor volume, GTV), location and Child-Pugh score in stereotactic body radiation therapy (SBRT) of liver cancer. Methods / Materials: Translational motion data of 146 liver cancer patients, who were previously treated with free breathing under tumor tracking, were analyzed. Before treatment 3-8 gold fiducial markers (0.8x5mm) were implanted near the target in order to be tracked by the tumor tracking system. Target motion data was automatically recorded in the log files of motion tracking system. Each of the following clinical factors was evaluated to determine its correlation with the amplitude of movement: target location (liver lobe), Child Pugh score, GTV size and intra-fraction treatment time. Results: Target location correlated with the translational motion in Superior / Inferior (SI) (p=0.021) and Left / Right (LR) directions (p=0.007) but not Anterior / Posterior (AP) direction (p=0.398). Child Pugh score and GTV size did not show any significant correlation with target motions in SI, LR and AP directions. Intra-fraction treatment time was also found statistically significant on target translational motion in SI (p=0.020) and LR (p=0.005), while it was insignificant in AP-direction (p=0.085). However, the correlation was fairly weak with R-square = 0.037 (SI) and 0.055 (LR) respectively. Conclusions: The target motion in SI and LR directions caused by respiratory motion were correlated with the location of target. The change in target motion amplitude showed no apparent relationship with, Child-Pugh scores and GTV sizes, but a fairly weak relationship with the intra-fraction treatment time.
Rights: All rights reserved
Access: restricted access

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