Author: Li, Jiahao
Title: A double-decker abdominal window for long-term and real-time high-speed photoacoustic microscopic imaging of hepatic lobules
Degree: M.Sc.
Year: 2024
Subject: Liver -- Diseases -- Imaging
Diagnostic imaging
Hong Kong Polytechnic University -- Dissertations
Department: Department of Biomedical Engineering
Pages: iii, 32 pages : color illustrations
Language: English
Abstract: The liver is an essential digestive, immune, and endocrine organ that retains one of the most unique vascular structures of the body. The variations in the morphology and physiology of these hepatic vessels, especially the hepatic sinuses, may show the signs of lesions of the liver which may provide more diagnostic information with higher accuracy. Since the photoacoustic imaging modality has the potential to visualize the vascular structures and the hematologic metabolisms, anatomical, functional, and molecular imaging by using photoacoustic microscopy (PAM) on the liver could be one of the obvious choices. Due to the scattering effect and the low penetration of the visible laser in tissues and organs, the abdominal window is required for liver PAM imaging in mice. This article will introduce a double-decker structural abdominal window that could physically fix the liver during the imaging process to improve the quality of PAM imaging by minimizing the motion artifacts. The double-decker structural abdominal window would be suitable for most of the hepatic disease models and also provide long-term imaging to visualize the morphological and physiological changes of hepatic lobules with high resolution. Also, a foundational high-speed PAM imaging system based on galvanometer scanning would be built up to perform real-time imaging to monitor the dynamics of the hepatic sinuses.
Rights: All rights reserved
Access: restricted access

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