| Author: | Chan, Shui Yi |
| Title: | Assessment of matrix metalloproteinase-9 activity in metabolic syndrome |
| Degree: | M.Sc. |
| Year: | 2013 |
| Subject: | Metabolic syndrome. Metalloproteinases. Extracellular matrix proteins. Hong Kong Polytechnic University -- Dissertations |
| Department: | Department of Health Technology and Informatics |
| Pages: | viii, 77 leaves : ill. ; 30 cm. |
| Language: | English |
| Abstract: | The prevalence of the metabolic syndrome is increasing worldwide. The syndrome is associated with the cardiovascular risk with an increased morbidity and mortality. A pathophysiological mechanism responsible for the increased risk has not been elucidated. Abnormal MMP-9 activity, which contributes to pathological vascular remodeling, may be one of the components linking the metabolic syndrome to the development of cardiovascular disease. In this project, the alteration of MMP-9 activity on patient with metabolic syndrome and their association with metabolic syndrome component were studied. In our study, no significant difference of total level of free MMP-9 level was found between subjects with and without metabolic syndrome. No correction was found among the total level of free MMP-9 and the components of the metabolic components including the level of glucose, triglyceride, blood pressure, HDL and waist circumference, but significant difference of total level of free MMP-9 was found between the aged group and the young group of the subject. In conclusion, no difference on the total level of free MMP-9 was shown in metabolic syndrome patient compared with healthy subjects. The increased total level of free MMP-9 found in aged group might suggest a possibly relevant pathophysiological mechanism that involved in the increase of cardiovascular risk associated with aging. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b26370992.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 436.74 kB | Adobe PDF | View/Open |
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