Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Interdisciplinary Division of Biomedical Engineering | en_US |
| dc.creator | Yu, Sihang | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/7558 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Longitudinal characterization and interpretation of functional parameters during zebrafish heart regeneration | en_US |
| dcterms.abstract | In this project, we propose a characterization model that provides a comprehensive depiction as well as interpretation of cardiac contractility during the regeneration process of zebrafish. The 20% ventricle amputated zebrafish will serve as an experimental model for studying how the cardiac functions are regained after myocardial infarction. The Doppler spectrogram is first generated using Matlab based on traditional Pulse wave Doppler signal processing techniques. Doppler mode indices such as E/A ratio and deceleration time (DT) are then examined longitudinally. We were able to verify from a functional level that the increased E/A velocity ratio, which often reflects impaired ventricle relaxation, can also be found during zebrafish regeneration process. As the heart gradually replaces the scar tissue with newly differentiated myocardium, the ventricle regains its compliance and realizes its functional recovery. The E/A ratio gradually returns to the initial value. In addition, smoothing techniques were preforming on the Doppler signal in the hope that errors caused factors such as measurement angles may be reduced and the measurements on the Doppler spectrogram can be therefore improved. | en_US |
| dcterms.extent | vii, 40 leaves : illustrations ; 30 cm | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2014 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Heart function tests | en_US |
| dcterms.LCSH | Heart -- Research | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b27577442.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.75 MB | Adobe PDF | View/Open |
Copyright Undertaking
As a bona fide Library user, I declare that:
- I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
- I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
- I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.
Please use this identifier to cite or link to this item:
https://theses.lib.polyu.edu.hk/handle/200/7558