| Author: | Yu, Sihang |
| Title: | Longitudinal characterization and interpretation of functional parameters during zebrafish heart regeneration |
| Degree: | M.Sc. |
| Year: | 2014 |
| Subject: | Heart function tests Heart -- Research Hong Kong Polytechnic University -- Dissertations |
| Department: | Interdisciplinary Division of Biomedical Engineering |
| Pages: | vii, 40 leaves : illustrations ; 30 cm |
| Language: | English |
| Abstract: | In this project, we propose a characterization model that provides a comprehensive depiction as well as interpretation of cardiac contractility during the regeneration process of zebrafish. The 20% ventricle amputated zebrafish will serve as an experimental model for studying how the cardiac functions are regained after myocardial infarction. The Doppler spectrogram is first generated using Matlab based on traditional Pulse wave Doppler signal processing techniques. Doppler mode indices such as E/A ratio and deceleration time (DT) are then examined longitudinally. We were able to verify from a functional level that the increased E/A velocity ratio, which often reflects impaired ventricle relaxation, can also be found during zebrafish regeneration process. As the heart gradually replaces the scar tissue with newly differentiated myocardium, the ventricle regains its compliance and realizes its functional recovery. The E/A ratio gradually returns to the initial value. In addition, smoothing techniques were preforming on the Doppler signal in the hope that errors caused factors such as measurement angles may be reduced and the measurements on the Doppler spectrogram can be therefore improved. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b27577442.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.75 MB | Adobe PDF | View/Open |
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