Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.creator | Ng, Po Wah Lawrence | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/7595 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Analysis of MYB expression and MYB translocations in salivary gland and lacrimal gland adenoid cystic carcinomas | en_US |
| dcterms.abstract | A subset of Adenoid Cystic Carcinoma (ACC) is characterized by MYB fusions including the novel t(6;9)(q22-23; p23-24) translocation. There has been over expression in MYB RNA in ACCs regardless to MYB fusions. Retrospective study of formalin-fixed paraffin embedded (FFPE) samples of 21 salivary gland ACCs and 3 lacrimal gland ACCs together with 6 non-ACC salivary gland tumors were studied. As a result, MYB-NFIB fusion transcripts in salivary gland adenoid cystic carcinoma and lacrimal gland carcinoma were 9% and 50% respectively with an overall frequency of 15%. No MYB-NFIB fusion transcripts were identified in all non-ACC of salivary gland, suggestive of a high specificity of MYB-NFIB fusion in ACC of salivary gland. Sixty-seven percent of salivary gland ACC were MYB fusion positive. In case of lacrimal gland ACC, all cases were fusion positive. The overall frequency of MYB fusions was therefore 71%. MYB expression was found in 80% and 67% of fusion-positive salivary gland and fusion-positive lacrimal gland ACCs and was about 67% of fusion-negative salivary gland ACCs despite of low expression in fusion-negative ACCs. MYB over expression didn't appear in other salivary gland tumors. Overall percentage of MYB expression in ACC samples was 75% whereas the percentages of MYB expression in fusion positive and negative ACC samples were 78% and 67% respectively. Hence, MYB can be counted as a major oncogene in ACC pathogenesis. | en_US |
| dcterms.extent | x, 63 leaves : color illustrations ; 30 cm | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2014 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | DNA-binding proteins. | en_US |
| dcterms.LCSH | Adenoid cystic carcinoma | en_US |
| dcterms.LCSH | Genetic transcription. | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b2759015x.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 912.62 kB | Adobe PDF | View/Open |
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